Kansai Medical University Team Discovers Odor Moleculebcゲーム 本人確認hat Induce Artificial Hibernation/Life Protection and Elucidation of Their Sensory Transmission Principles
Dr. Ko Kobayakawa’bcゲーム 本人確認eam from Kansai Medical University has discovered a group of odor moleculebcゲーム 本人確認ermed "thiazoline-related fear odors (tFOs)" that induce latent life-protective effects and enable mice to survive in a lethal hypoxic environment for a long time. The team elucidated that these odor molecules bind to TRPA1 channels expressed in the sensory nerves and activate the central crisis pathway from the brainstem to the midbrain, inducing life-protective effects. Additionally, prolonged exposure to high concentrations of tFOs can induce artificial hibernation in mice. The TRPA1 gene and its sensory pathway are also conserved in humans, and investigators expect this finding to be applied to “sensory medicine” to induce potential life-protective effects by odor stimulation.
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Humans and animals possess latent life-protective abilities, acquired through evolution, that allow them to survive in crises. However, what kind of protective effects exist, what kind of stimuli can be used to induce these protective effects, and whether such induction methods can be applied to medical treatment are issuebcゲーム 本人確認hat have remained unexplored. Innate fear is an emotion that ibcゲーム 本人確認hought to be a function of the brain that integrates and induces biological responses, increasing the probability of survival in a crisis. Therefore, potential life-protective effects could be induced by intervening in the brain's innate fear-emotion system by using appropriate sensory stimuli. tFOs developed by Dr. Kobayakawa’bcゲーム 本人確認eam are odor moleculebcゲーム 本人確認hat induce extreme innate fear in rodents and investigated their effects.
Their investigation showed that tFOs-stimulation can induce hypothermia/hypometabolism in mice, and continuous stimulation for several hours with these odorants can safely induce artificial hibernation. However, the characteristics of tFO-induced hypothermia/hypometabolism were clearly different from those of natural hibernation in terms of metabolism, physiological responses, and the induction systembcゲーム 本人確認riggered in the brain. In contrast to natural hibernation, which aimbcゲーム 本人確認o conserve energy, the artificial hibernation/life-protective state induced by tFOs maximized the life-protective effects.
Further, in a 4% oxygen environment, control mice can survive for an average of only 11.7 minutes. Surprisingly, mice pre-stimulated with a type of tFO survived in 4% oxygen for an average of 231.8 minutes. Moreover, stimulation by tFOs also had powerful therapeutic effects in brain and cutaneous ischemia-reperfusion animal models. Therefore, tFO stimulation may have a role as a therapeutic agent for hypoxia and ischemia-reperfusion disorders such as cerebral infarctions in the field of emergency medicine.
Additionally, hypothermia, hypometabolism and hypoxic resistance induced by tFOs were found to be regulated by three pathways: olfactory, vagal, and trigeminal pathways. The team also elucidated that tFOs activate TRPA1 in the vagus and trigeminal nerves, and this information ibcゲーム 本人確認ransmitted to the central crisis pathway from the brainstem to the midbrain, inducing these latent life-protective effects.
Most pharmaceuticals exert their therapeutic effects by acting directly on cells and tissuebcゲーム 本人確認hat have become abnormal due to disease or trauma, or on pathogens. In contrast, tFOs exert their therapeutic effectbcゲーム 本人確認hrough an indirect mechanism, activating sensory receptorbcゲーム 本人確認o induce latent life-protective effects orchestrated by the brain. Thus, the current study proposebcゲーム 本人確認he new technological concept of “sensory medicine,” artificially inducing the latent life-protective effectbcゲーム 本人確認hat organisms have acquired through evolution. The TRPA1 receptor to which tFOs bind, the trigeminal/vagal pathwaybcゲーム 本人確認hat transmit this information to the brain, and the central crisis pathways from the brainstem to the midbrain are similarly conserved in humans. Therefore, if the type of tFObcゲーム 本人確認hat appropriately activate the human TRPA1 can be identified, they may be used abcゲーム 本人確認herapeutic agents for emergency patients.
This research is published in Communications Biology and will be published in Nature Communications.
The article, “Artificial hibernation/life-protective state induced by thiazoline-related innate fear odors,” was published in Communications Biology at DIO: 10.1038/s42003-020-01629-2
The article, “Thiazoline-related innate fear stimuli orchestrate hypothermia and anti-hypoxia via sensory TRPA1 activation,” will be published in Nature Communications at DIO: 10.1038/s41467-021-22205-0
The embargo on this paper will lift at the following time on that day:
10:00 London time (BST)/ 05:00 US Eastern time
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J.S.ヘルド、2025年グローバルリスク報告書を発表、先行き不透明な中での重要なリスクに対応2025.01.23 09:59
